Living Donation

Living organ donation offers another choice for some transplant candidates, reducing their time on the waiting list and leading to better long term outcomes for the recipient.

Living tissue donation, birth tissue, is used to promote healing and to treat burns and painful wounds.

The Need

A living donor is an option for patients who otherwise may face a lengthy wait for an organ from a deceased donor. To spare an individual a long and uncertain wait, relatives, loved ones, friends, and even individuals who wish to remain anonymous may serve as living donors.

Kidney and liver transplant candidates who are able to receive a living donor transplant can receive the best quality organ much sooner, often in less than a year.

  • More than 100,000 people are on the national transplant waiting list.
  • More than 85% of patients waiting are in need of a kidney.
  • 11% of patients waiting are in need of a liver.
  • In 2020, 5,700 more lives were saved through the generosity of living donors. 

Facts about Living Donation

Want to learn more about living donation? Here are some key facts:

  • Living donation is an opportunity to save a life while you are still alive.
  • Living organ donation and transplantation was developed as a direct result of the critical shortage of deceased donors. 
  • Living donors don’t have to be related to their recipients. On average, 1 in 4 living donors are not biologically related to the recipient.
  • Patients who receive a living donor transplant are removed from the national transplant waiting list, making the gift of a deceased donor kidney or liver available for someone else in need.

If you are considering being a living donor, it’s important to note that living donation is not included in your deceased donor registration. In 2021, you will be able to register your interest in being a living donor in the National Donate Life Living Donor Registry (check back for updated information). A living donor transplant program will conduct a full evaluation to determine your eligibility to be a living donor.

The National Donate Life Living Donor Registry

In 2022, Donate Life America is launching the National Donate Life Living Donor Registry, a national-reaching living donor registry with the goal of reducing access barriers for prospective living donors.

Individuals between the ages of 18-65 who register their decision to be a deceased organ, eye and tissue donor through the National Donate Life Registry, RegisterMe.org, will also be offered the opportunity to register their interest in being a living kidney donor.

The development of the National Donate Life Living Donor Registry is being generously funded by the Fresenius Medical Care Foundation, and DLA is working with key partners including: United Network for Organ Sharing (UNOS), LifeLogics, CareDx, and the National Kidney Foundation (NKF).

Donate Life America completed the pilot phase of the National Donate Life Living Donor Registry in October 2021. A regional launch of the National Donate Life Living Donor Registry will begin in December 2021.

For additional information or questions, please contact: LivingDonation@DonateLife.net

 

 

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Types of Living Donation

Directed Donation

In a directed donation, the living donor names the specific person to receive the transplant. This is the most common type of living donation. In a directed donation, the living donor may be:

  • a biological relative, such as a parent, brother, sister, or adult child
  • a biologically unrelated person who has a personal or social connection with the transplant candidate, such as a spouse or significant other, a friend or a coworker
  • a biologically unrelated person who has heard about the transplant candidate’s need

If tests reveal that the living donor would not be a good medical match, paired donation may be an option.

Non-Directed Donation

In non-directed donation, the living donor does not name the specific person to receive transplant. The match is determined based on medical compatibility with a patient on the national transplant waiting list. The living donor and recipient may meet at some time, if they both agree, and depending on transplant hospital policy and guidance.

Kidney Paired Donation

According to UNOS, kidney paired donation (KPD), also called kidney exchange, occurs when a transplant candidate has someone who wants to donate a kidney to them, but tests reveal that the kidney would not be a good medical match. Kidney paired donation gives that transplant candidate another option: swapping living donor kidneys so each recipient receives a compatible transplant.

This type of exchange often involves multiple living kidney donor/transplant candidate pairs. View transplant centers that currently participate in the OPTN Kidney Paired Donation (KPD) Pilot Project.

Tissue Donation

Birth tissue is gestational tissue that can be donated after the delivery of a living newborn. Donated birth tissue is often used in reconstructive procedures to promote healing, and to treat burns and painful wounds. Birth tissue donation is a type of living donation and does not impact your health or the health of your baby.

Donated birth tissue can include:

Placenta
Amniotic membrane
Chorionic membrane
Amniotic fluid
Umbilical cord tissue
Umbilical veins
Wharton’s jelly
Birth tissue and cord blood can be donated after childbirth and require a specific authorization.

Who Can Donate?

Living donors should be in good overall physical and mental health and older than 18 years of age. Some medical conditions could prevent an individual from being a living donor. Since some donor health conditions could harm a transplant recipient, it is important that living donor candidates share all information about their physical and mental health. It is important to be fully informed of the known risks involved with donating and complete a full medical and psychosocial evaluation. The decision to donate should be completely voluntary and free of pressure or guilt, and donors can delay or stop the process at any time.

Risks of Living Donation

Living donation is a major surgery, and all potential complications of major surgery apply. These complications may include:

  • pain
  • infection at the incision site
  • incisional hernia
  • pneumonia
  • blood clots
  • hemorrhaging
  • potential need for blood transfusions
  • side effects associated with allergic reactions to the anesthesia
  • death

According to the National Kidney Foundation, living donors in studies report a boost in self-esteem, and 9 out of 10 say they would do it again. However, living donors may also experience negative psychological symptoms right after donation or later. The transplanted organ may not work right away. There is also the chance it will not work at all. Donors may feel sad, anxious, angry, or resentful after surgery. Donation may change the relationship between donor and recipient.

The best source of information about risks and expected donor outcomes is the transplant team. In addition, it is important to take an active role in learning more about these potential surgical risks and long-term complications.

Living donors must be made aware of the physical and psychological risks involved before they consent to donate an organ. Please discuss all feelings, questions and concerns with a transplant professional and/or social worker.

How to Become a Living Donor

For more information on how to start the process of becoming a living donor, contact a living donor transplant program in your area. You can find contact information for living donor transplant programs and other helpful patient information at UNOS TransplantLiving.org.

Laurell and Katherine’s Living Donation Story

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“Because of Katherine, we are planning for life again,” says Laurell. “Katherine is a beautiful soul.” Click here to read their full story.

 

References: TransplantLiving.org, UNOS.org, OPTN.transplant.HRSA.gov, and Kidney.org.

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